When the bacteriostatic antibiotic is removed from the system, normal growth of bacteria can be observed. Bacteriostatic antibiotics inhibit bacterial DNA replication, protein synthesis and other aspects of bacterial metabolism. These antibiotics work along with the immune system of the host in order to prevent the bacterial growth and reproduction. High concentrations of some of the bacteriostatic antibiotics can be bactericidal. Tetracyclines, spectinomycin, chloramphenicol, sulfonamides, trimethoprim, lincosamides, and macrolides are examples of bacteriostatic antibiotics.
The minimum inhibitory concentration MIC is the minimum drug concentration which inhibits the bacterial growth. The inhibition of the successive steps of tetrahydrofolate synthesis pathway by sulfonamides and trimethoprim is shown in figure 2. Tetrahydrofolate is involved in the nucleotide synthesis. Ultimately, the inhibition of the production of tetrahydrofolate leads to defective DNA replication.
Figure 2: Inhibition of Tetrahydrofolate Synthesis Pathway. Bactericidal: The antibiotics that kill bacteria are referred to as bactericidal. Bacteriostatic: The antibiotics that prevent the growth of bacteria are referred to as bacteriostatic. Bactericidal: Bactericidal antibiotics kill bacteria.
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David J. Watson, and Johnathan Elliot. User assumes all risk of use, damage, or injury. You agree that we have no liability for any damages. What is Bactericidal? What is Bacteriostatic? Bactericidal Vs. Bacteriostatic 1. Classification of Bactericidal and Bacteriostatic These are both antibiotics, with bactericidal drugs classified as bacteria-killing, and bacteriostatic drugs as bacteria-inhibiting.
Action of Bactericidal Vs. Bacteriostatic Generally, bactericidal antibiotics cause cell death by preventing cell wall synthesis of the bacterial cell. Application The application differs according to the type of bacterial infection, since certain antibiotics may be bactericidal in some cases while acting as a bacteriostatic drug when confronted with a different strain of bacteria. Side effects Bactericidal drugs with a rapid mode of action will often stimulate severe inflammation due to the release of bacterial cell contents upon cell death, which can result in toxic shock syndrome.
Clinical considerations The outcome can be affected by various factors, including the bacterial density, host immune response, underlying disease or the site of infection.
When bacteriostatic agents are utilized, the treatment will regulate the number of bacterial cells. While the bacteria will not be eliminated, their numbers will not increase. Bacteriostatic substances produce reversible results. Bactericidal products eliminate bacteria while bacteriostatic products keep bacterial populations in check by inhibiting replication. This is an irreversible process as the bacteria is killed and cannot be reversed. Some of the bactericidal antibiotics are also said to inhibit protein synthesis and inhibit bacterial lipids and enzymes.
Some of the drugs opt for more than one mode of action. The bactericidal antibiotics, when used in cases of rapidly dividing bacteria, show the most action. The concentration of the antibiotic required to kill Bactericidal can be referred to as any substance that kills bacteria.
Examples include disinfectants, antibiotics, and antiseptics. These activities are used in hospitals and other healthcare facilities to completely kill the bacteria on the surface of the things in order to produce an aseptic environment. This is especially done in operation theaters and intensive care units.
Common chemicals used in case of disinfecting are alcohol. Bacteriostatic is the specific category of antibiotics that inactivates the bacteria by limiting its growth and multiplication of cells, i.
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